1402444-77-2Relevant articles and documents
Supermacrocyclic Assemblies by Hydrogen-Bond Codes of C7-Phenol Pyrazolo and Pyrrolo Derivatives of Adenine
Chai, Yingying,Zhou, Xinglong,Li, Changfu,Ma, Beibei,Shen, Zhen,Huang, Ridong,Chen, Hai,Chen, Bojiang,Li, Weimin,He, Yang
, p. 15495 - 15501 (2018)
Hydrogen bond (HB) mediated base pair motifs are versatile scaffolds of diverse supramolecular constructs. Here, we report that two new four- and six-membered supermacrocyclic assemblies with intriguing geometries could self-assemble from two new adenine derivatives, APN (1) and APC (2). The conversion of a conventional HB acceptor, N8 of 1, to a non-conventional HB donor, C8?H of 2, had a pronounced impact on the overall intricate HB network and self-assembly patterns, epitomizing the subtleties in design and exploitation of such base-pair motifs as promising tectons for building supramolecular architectures.
ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY
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Page/Page column 34, (2019/01/10)
The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly inter
FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
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Paragraph 1532; 1533, (2018/02/06)
The present invention provides a novel RET inhibitor comprising, as an active ingredient, a compound or a salt thereof that have not been known for their RET inhibitory activity, and also provides an agent for preventing or treating diseases (e.g., malign
