1402614-36-1Relevant articles and documents
Discovery of non-LBD inhibitor for androgen receptor by structure-guide design
Ryu, Byung Jun,Kim, Nakjeong,Kim, Jun Tae,Koo, Tae-Sung,Yoo, Sung-Eun,Jeong, Seo Hee,Kim, Seong Hwan,Kang, Nam Sook
, p. 3887 - 3890 (2013/07/27)
In this study, we synthesized the BF-3 binding small molecules, a series of pyridazinone-based compounds, as a novel class of non-LBP antiandrogens for treating prostate cancer by inhibiting androgen receptor. The new class compound was discovered to inhibitor the viability of AR-dependent human prostate LNCap cells and AR activity combining with the computational method. It showed a good physicochemical and PK property.