14027-53-3

Usage

Derivative of benzene

1-methyl-4-(prop-1-yn-1-ylsulfonyl)benzene is derived from the benzene structure, with modifications made to its hydrogen atoms.

Methyl group at position 1

A methyl group (CH3) is attached to the first position of the benzene ring, contributing to the compound's structure.

Prop-1-yn-1-ylsulfonyl group at position 4

A prop-1-yn-1-ylsulfonyl group (CH3CH2C≡C-SO2-) is attached to the fourth position of the benzene ring, further modifying the structure.

Building block in organic synthesis

1-methyl-4-(prop-1-yn-1-ylsulfonyl)benzene is often used as a starting material for synthesizing other organic compounds, particularly in the pharmaceutical industry.

Production of drugs and pharmaceutical intermediates

1-methyl-4-(prop-1-yn-1-ylsulfonyl)benzene can be utilized in the synthesis of various drugs and intermediates, making it an important component in the development of new medications.

Potential applications in material science

1-methyl-4-(prop-1-yn-1-ylsulfonyl)benzene may have uses in the field of material science, possibly contributing to the development of new materials with unique properties.

Organic chemistry research

The compound's unique structure and reactivity make it a valuable subject for research in organic chemistry, potentially leading to new discoveries and advancements in the field.

Wide range of potential uses

Due to its versatile structure and reactivity, 1-methyl-4-(prop-1-yn-1-ylsulfonyl)benzene has the potential to be used in various industries, making it a valuable compound for further exploration and development.

Upstream product

• 6224-91-5 trimethyl(prop-1-ynyl)silane 
• 98-59-9 p-toluenesulfonyl chloride 
• 10486-08-5 sodium p-thiocresolate 
• 33597-89-6 4-methylphenyl prop-2'-ynyl sulfide 
• 68819-94-3 p-tolyl benzeneselenosulfonate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 142363-45-9 1-propynyl(phenyl)iodonium triflate 
• 40890-29-7 prop-1-yn-1-yl(p-tolyl)sulfide 

Downstream Products

• 36832-55-0 2-Benzoyloxy-1-(p-toluol-sulfonyl)-propen-⁽²⁾ 
• 877122-49-1 (Z)-1-((2-bromoprop-1-en-1-yl)sulfonyl)-4-methylbenzene 
• 5366-49-4 4-toluenesulfonylacetone 

Relevant academic research and scientific papers

Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio- and Stereoselective Synthesis of Trifluoromethoxylated Alkenes

The trifluoromethoxy group has elicited much interest among drug and agrochemical discovery teams because of its unique properties. We developed trifluoromethyl nonafluorobutanesulfonate (nonaflate), TFNf, an easy-to-handle, bench-stable, reactive, and scalable trifluoromethoxylating reagent. TFNf is easily and safely prepared in a simple process in large scale and the nonaflyl part of TFNf can easily be recovered as nonaflyl fluoride after usage and recycled. The synthetic potency of TFNf was showcased with the underexplored synthesis of various trifluoromethoxylated alkenes, through a high regio- and stereoselective hydro(halo)trifluoromethoxylation of alkyne derivatives such as haloalkynes, alkynyl esters, and alkynyl sulfones. The synthetic merits of TFNf were further underscored with a high-yielding and smooth nucleophilic trifluoromethoxylation of alkyl triflates/bromides and primary/secondary alcohols.

Cu(OAc)2 Mediated Synthesis of 3-Sulfonyl Chromen-4-ones

Copper acetate mediated (4 + 2) annulation of sulfonylacetylenes with salicylic acids provides sulfonyl chromen-4-ones in the presence of benzotriazol-1-yloxy tri(dimethylamino)phosphonium hexafluorophosphate (BOP, Castro's reagent) and 4-dimethylaminopyridine (DMAP) in MeNO2 at reflux for 3 h. The uses of various metal complexes and activating reagents are investigated for facile and efficient transformation. A plausible mechanism is proposed.

A Desulfonylative Approach in Oxidative Gold Catalysis: Regiospecific Access to Donor-Substituted Acyl Gold Carbenes

Donor-substituted acyl gold carbenes are challenging to access selectively by gold-promoted intermolecular oxidation of internal alkynes as the opposite regioisomers frequently predominate. By using alkynyl sulfones or sulfonates as substrates, the oxidative gold catalysis in the presence of substituted pyridine N-oxides offers regiospecific access to acyl/aryl, acyl/alkenyl, and acyl/alkoxy gold carbenes by in situ expulsion of sulfur dioxide. The intermediacies of these reactive species are established by their reactivities, including undergoing further oxidation by the same oxidant, cyclopropanation of styrenes, engaging in a [3+2] cycloaddition with α-methylstyrene, and conversion into dienones. Accept it: A desulfonylative approach was developed to regiospecifically access these underexplored acyl gold carbenes from either alkynyl aryl/alkenyl sulfones or alkynyl sulfonate substrates. The reactivities of these donor- and acceptor-substituted carbenes are examined.

Synthesis of the quinolizidine alkaloids (-)-lasubine II and (±)-myrtine by conjugate addition and intramolecular acylation of amino esters with acetylenic sulfones

(Chemical Equation Presented) The conjugate additions of (2-piperidyl)acetate esters to acetylenic sulfones, followed by LDA-promoted intramolecular acylations, afforded cyclic enaminones that were readily converted into the corresponding 4-substituted 2-

A New Synthesis of Alkynyl Sulfones and Single Crystal X-ray Structure of p-(Tolylsulfonyl)ethyne

The reaction of mono- or bis(alkynyliodonium) triflate salts with sodium p-toluenesulfinate under mild conditions affords alkynyl sulfones in 60-95percent yields.