1402727-29-0 Usage
Description
PE859 is a compound with potential applications in various industries, particularly as a tau aggregation inhibitor for the treatment of Alzheimer's disease.
Uses
Used in Pharmaceutical Industry:
PE859 is used as a potent tau aggregation inhibitor for the treatment of Alzheimer's disease. Its ability to inhibit tau aggregation makes it a promising candidate for drug development in the fight against this neurodegenerative condition.
Enzyme inhibitor
This orally bioavailable tau aggregation inhibitor (FW = 448.53 g/mol; IUPAC: 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2- pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole) significantly reduces formation of sarkosyl-insoluble aggregates of Tau, the principal axonal microtubule-associated protein, and prevents onset and progression of the motor dysfunction in JNPL3 Pro-301-Leu-mutated human tau transgenic mice. PE859 also inhibits aggregation of three-repeat Tau, or 3RMBD-Tau (IC50 = 0.81 μM), and four-repeat Tau, or 2N4R-Tau (IC50 = 2.23 μM).
Check Digit Verification of cas no
The CAS Registry Mumber 1402727-29-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,2,7,2 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1402727-29:
(9*1)+(8*4)+(7*0)+(6*2)+(5*7)+(4*2)+(3*7)+(2*2)+(1*9)=130
130 % 10 = 0
So 1402727-29-0 is a valid CAS Registry Number.
1402727-29-0Relevant articles and documents
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors
Okuda, Michiaki,Hijikuro, Ichiro,Fujita, Yuki,Teruya, Takayuki,Kawakami, Hirochika,Takahashi, Takashi,Sugimoto, Hachiro
, p. 5024 - 5028 (2016/10/05)
Alzheimer's disease (AD) is the most common form of dementia. In an AD patient's brain, senile plaques and neurofibrillary tangles, the abnormal aggregates of amyloid β (Aβ) peptide and tau protein, are observed as the two major hallmarks of this disease.
