1196-70-9

Basic information

• Product Name: Indole-6-carboxaldehyde
• Synonyms: 6-FORMYLINDOLE;1H-INDOLE-5-CARBOXALDEHYDE;1H-INDOLE-5-CARBALDEHYDE;1H-INDOLE-6-CARBALDEHYDE;INDOLE-6-CARBALDEHYDE;INDOLE-6-CARBOXALDEHYDE;INDOLE-6-CARBOXALEHYDE;INDOLE-6-ALDEHYDE
• CAS NO: 1196-70-9
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.16
• Product Categories: ALDEHYDE;Nitrogen cyclic compounds;Aldehydes;blocks;IndolesOxindoles;Indoles and derivatives;Indole;Indoles;Building Blocks;Indole Derivatives;Heterocycle-Indole series
• Mol File: 1196-70-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 127-131 °C(lit.)
• Boiling Point: 339.071 °C at 760 mmHg
• Flash Point: 166.84 °C
• Appearance: Yellow to orange to brown/Crystalline Powder
• Density: 1.278 g/cm³
• Storage Temp.: Keep Cold
• Solubility: Chloroform, Dichloromethane
• PKA: 15.84±0.30(Predicted)
• CAS DataBase Reference: Indole-6-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Indole-6-carboxaldehyde(1196-70-9)
• EPA Substance Registry System: Indole-6-carboxaldehyde(1196-70-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1196-70-9(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

Uses

Different sources of media describe the Uses of 1196-70-9 differently. You can refer to the following data:
1. Reactant in preparation of analogs of botulinum neurotoxin serotype A protease inhibitors 1 Reactant in synthesis of stilbene-based antitumor agents 2 Reactant in acid-catalyzed preparation of aromatic gem-dihalides from aldehydes and acid halides.
2. Indole-6-carboxaldehyde (cas# 1196-70-9) is a compound useful in organic synthesis.

InChI:InChI=1/C9H7NO/c11-6-7-1-2-8-3-4-10-9(8)5-7/h1-6,10H

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 1075-26-9 6-(hydroxymethyl)indole 
• 32989-68-7 trans-4-(β-dimethylaminovinyl)-3-nitrobenzaldehyde 
• 127956-27-8 6-(difluoromethyl)indole 
• 3420-02-8 6-methylindole 
• 127956-24-5 tert-butyl 6-methyl-1H-indole-1-carboxylate 
• 127956-28-9 1-(tert-butoxycarbonyl)-1H-indole-6-carboxaldehyde 
• 127956-25-6 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole 
• 127956-29-0 tert-butyl 6-(difluoromethyl)-1H-indole-1-carboxylate 
• 1670-82-2 Indole-6-carboxylic acid 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 15861-36-6 1H-Indole-6-carbonitrile 
• 40870-59-5 (4-Methyl-3-nitro-phenyl)-methanol 

Downstream Products

• 127956-28-9 1-(tert-butoxycarbonyl)-1H-indole-6-carboxaldehyde 
• 21005-45-8 1-methyl-1H-indole-6-carboxaldehyde 
• 642443-00-3 2-[5-(3,4-dimethoxy-phenyl)-pyrimidin-2-ylsulfanyl]-N-[1-(1H-indol-6-ylmethyl)-piperidin-3-ylmethyl]-acetamide 
• 1177251-92-1 6-[(1-benzyl-1H-tetrazol-5-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methyl]-1H-indole 
• 1198207-34-9 (1E,6E)-1-(2-bromo-5-hydroxyphenyl)-7-(1H-indol-6-yl)hepta-1,6-diene-3,5-dione 
• 1298129-83-5 3-[6-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid 
• 1298129-79-9 6-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester 
• 1298129-85-7 3-[6-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid ethyl ester 
• 1396723-05-9 methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate 
• 1593929-08-8 (E)-3-(1-(3-bromobenzyl)-1H-indol-6-yl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)prop-2-en-1-one 

Relevant articles and documents

SYNTHESIS AND REACTIVITY OF 6-(FLUOROMETHYL)INDOLE AND 6-(DIFLUOROMETHYL)INDOLE

The N-1 BOC protected precursors of 6-(fluoromethyl)indole and 6-(difluoromethyl)indole were prepared and deprotected via flash vacuum thermolysis.The stability of these newly prepared, unprotected indole derivatives has been characterized and compared to that of a previously known compound, 6(trifluoromethyl)indole.

N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR

The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia

HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY

In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.