1402730-13-5

Basic information

• Product Name: (R)-benzyl 1-(5-amino-1H-pyrazol-3-yl)ethylcarbamate
• Synonyms: (R)-benzyl 1-(5-amino-1H-pyrazol-3-yl)ethylcarbamate
• CAS NO: 1402730-13-5
• Molecular Weight: 260.296
• Mol File: 1402730-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-benzyl 1-(5-amino-1H-pyrazol-3-yl)ethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-benzyl 1-(5-amino-1H-pyrazol-3-yl)ethylcarbamate(1402730-13-5)
• EPA Substance Registry System: (R)-benzyl 1-(5-amino-1H-pyrazol-3-yl)ethylcarbamate(1402730-13-5)

Safety Data

• Hazardous Substances Data: 1402730-13-5(Hazardous Substances Data)

Upstream product

• 852248-32-9 (3-bromo-1-(R)-methyl-2-oxopropyl)carbamic acid benzyl ester 
• 1402729-95-6 Z-D-Ala-CH₂CN 
• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 68223-06-3 (3-diazo-1-(R)-methyl-2-oxopropyl)carbamic acid benzyl ester 

Relevant articles and documents

Synthesis of N-urethane protected α-aminoalkyl-α-cyanomethyl ketones; Application to the synthesis of 3-substituted 5-amino-1H-pyrazole tethered peptidomimetics

The preparation of N-protected amino/peptide α-cyanomethyl ketones through cyanation of the corresponding α-bromomethyl ketones is described. The utility of the resulting α-cyanomethyl ketones in the synthesis of 3-substituted-5-amino-1H-pyrazoles has also been demonstrated. In both steps a wide range of N-protected amino/peptide acids has been employed and the products are obtained in good yield. The enantiomeric purity of both the α-cyanomethyl ketones and pyrazoles were confirmed by chiral HPLC analysis of the corresponding Z-protected d- and l-Ala-OH as model substrates. The synthesis of peptide pyrazolecarboxamides is also delineated. Georg Thieme Verlag Stuttgart · New York.