1402822-30-3Relevant academic research and scientific papers
Preparation and biological evaluation of 1′-cyano-2′-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors
Mish, Michael R.,Cho, Aesop,Kirschberg, Thorsten,Xu, Jie,Sebastian Zonte,Fenaux, Martijn,Park, Yeojin,Babusis, Darius,Feng, Joy Y.,Ray, Adrian S.,Kim, Choung U.
, p. 3092 - 3095 (2015/02/19)
The first synthesis of 1′-cyano-2′-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1′-unsubstituted counterparts and to the related 1′-cyan
1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
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Page/Page column 69-70, (2012/10/23)
Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
