1402832-87-4Relevant academic research and scientific papers
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides
Asami, Taiji,Nishizawa, Naoki,Ishibashi, Yoshihiro,Nishibori, Kimiko,Nakayama, Masaharu,Horikoshi, Yasuko,Matsumoto, Shin-Ichi,Yamaguchi, Masashi,Matsumoto, Hirokazu,Tarui, Naoki,Ohtaki, Tetsuya,Kitada, Chieko
, p. 6391 - 6396 (2012)
Metastin/kisspeptin, a 54-amino acid peptide, is the ligand of the G-protein-coupled receptor KISS1R which plays a key role in pathways that regulate reproduction and cell migration in many endocrine and gonadal tissues. The N-terminally truncated decapep
Metastin derivatives and use thereof
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Paragraph 0250, (2016/08/23)
The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
