1402850-59-2Relevant academic research and scientific papers
Benzofurazan N-Oxides as Mild Reagents for the Generation of α-Imino Gold Carbenes: Synthesis of Functionalized 7-Nitroindoles
Xu, Wei,Chen, Yulong,Wang, Ali,Liu, Yuanhong
, p. 7613 - 7618 (2019)
An efficient gold-catalyzed [3 + 2] annulation of benzofurazan N-oxides with ynamides has been developed, which provides a concise and regioselective access to highly functionalized 7-nitroindoles. Although N-oxides are often considered as oxygen transfer
Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides
Li, Ji-Lin,Lin,Han, Xiang-Lei,Li, Qingjiang,Wang, Honggen
supporting information, (2019/06/13)
A practical synthesis of α-fluorinated imides via the catalyst-free fluorohydroxylation of ynamides is developed. The reaction employs commercially available Selectfluor (F-TEDA-BF4) and H2O as the fluorine and hydroxyl sources, resp
Gold-Catalyzed [4+2]- and [3+3]-Annulations of Ynamides with 1-Yn-3-ols to Access Six-Membered Carbocycles and Oxacycles via Three Distinct Cyclizations
Giri, Sovan Sundar,Liu, Rai-Shung
, p. 3311 - 3318 (2017/09/13)
Three distinct strategies for catalytic annulations between ynamides and 1-yn-3-ols are described; the resulting carbo- and heterocycles were produced efficiently in one-pot operations using a gold catalyst. The chemoselectivities of these annulations are controlled by variations of the substituents of the ynamides and the 1-yn-3-ols. This reaction sequence involves initial alkoxylations of ynamides, followed by Claisen rearrangement of propargylic enol ethers, and ends with 6-endo-trig cyclizations of 1-allenyl-5-amide intermediates. Among these cascade annulations, the cyclizations of 5-allenyl-1-amides to yield 5,6-dihydro-2-pyranones and 6-alkylenecyclohex-2-ene-1-carboxamides are unprecedented in the literature. (Figure presented.).
Retention of stereochemistry in gold-catalyzed formal [4+3] cycloaddition of epoxides with arenynamides
Karad, Somnath Narayan,Bhunia, Sabyasachi,Liu, Rai-Shung
experimental part, p. 8722 - 8726 (2012/10/18)
Golden opportunity: [4+3] Cycloaddition reactions of arenynamides and epoxides are enabled under gold catalysis and have a broad substrate scope (see scheme; Ms=methanesulfonyl). An SN2-type front-side attack of phenyl at the oxiranyl ring is expected to cause the retention of stereochemistry. Copyright
