1402887-65-3Relevant academic research and scientific papers
Total synthesis of (-)-lemonomycin
Yoshida, Atsushi,Asakawa, Tomohiro,Hamashima, Yoshitaka,Kan, Toshiyuki,Akaiwa, Michinori,Yokoshima, Satoshi,Fukuyama, Tohru
supporting information, p. 11192 - 11195,4 (2012/12/12)
When life gives you lemons: An efficient and convergent enantioselective total synthesis of (-)-lemonomycin, which shows potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF), is presented. The key reaction steps are a Hosomi-Sakurai-type cyclization, a thermodynamically controlled Pictet-Spengler reaction, and a glycosidation reaction with lemonose (see scheme). Copyright
