1402929-98-9Relevant academic research and scientific papers
Design and synthesis of inhibitors of plasmodium falciparum N -myristoyltransferase, a promising target for antimalarial drug discovery
Yu, Zhiyong,Tate, Edward W.,Leatherbarrow, Robin J.,Brannigan, James A.,Brzozowski, A. Marek,Wilkinson, Anthony J.,Moss, David K.,Holder, Anthony A.
supporting information, p. 8879 - 8890,12 (2020/09/16)
Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum, the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focuse
