1402930-45-3Relevant academic research and scientific papers
NOVEL COMPOUNDS AND THEIR USE IN THERAPY
-
Page/Page column 63; 67, (2013/06/27)
The invention provides compounds which inhibit N-myristoyltransferase and are selective for protozoal N-myristoyltransferase and, consequently suitable to treat microbial infections, including viral and fungal infections, and protozoan infections such as malaria, leishmaniasis and sleeping sickness.
Design and synthesis of inhibitors of plasmodium falciparum N -myristoyltransferase, a promising target for antimalarial drug discovery
Yu, Zhiyong,Tate, Edward W.,Leatherbarrow, Robin J.,Brannigan, James A.,Brzozowski, A. Marek,Wilkinson, Anthony J.,Moss, David K.,Holder, Anthony A.
, p. 8879 - 8890,12 (2020/09/16)
Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum, the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focuse
