1402938-91-3

Upstream product

• 615-65-6 2-chloro-4-methyl-benzenamine 
• 98-88-4 benzoyl chloride 
• 77791-06-1 N-(2-chloro-4-methylphenyl)benzamide 
• 2038-57-5 3-Phenylpropan-1-amine 
• 1402938-81-1 (Z)-N-(2-chloro-4-methylphenyl)benzimidoyl chloride 

Relevant academic research and scientific papers

Benzimidazole compound with endothelial lipase inhibition effect and application of benzimidazole compound

The invention discloses a benzimidazole compound with an endothelial lipase inhibition effect and application of the benzimidazole compound, and belongs to the technical field of medicines. The benzimidazole compound has an excellent inhibition effect on endothelial lipase, can effectively treating atherosclerosis and sequelae thereof, such as coronary heart disease, and also promotes treatment onmetabolic syndrome and sequelae thereof, such as diabetes. The benzimidazole compound provided by the invention has good solubility in an aqueous medium, also has good biological activity and metabolic stability, and shows advantages in the aspect of serum stability.

Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors

N-(o-Halophenyl)imidoyl chlorides and the corresponding imidates are easily prepared and can be utilized as complementary precursors for the synthesis of important heterocycles. The synthesis of N-substituted benzimidazoles was possible from the palladium