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Microcin is a group of small protein-based antibacterial toxins produced by certain strains of Escherichia coli bacteria, which are part of the human gut microbiota. These toxins are ribosomally synthesized and post-translationally modified peptides that exhibit antimicrobial activity against other Gram-negative bacteria, including closely related E. coli strains. Microcin production is a form of bacterial competition, allowing the producing strain to outcompete other bacteria for resources. The microcin family includes various types, such as microcin B17, microcin J25, and microcin C7, each with unique structures and mechanisms of action. They are of interest in the field of microbiology and have potential applications in the development of novel antibiotics to combat antibiotic-resistant bacteria.

1403-96-9

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1403-96-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1403-96-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1403-96:
(6*1)+(5*4)+(4*0)+(3*3)+(2*9)+(1*6)=59
59 % 10 = 9
So 1403-96-9 is a valid CAS Registry Number.

1403-96-9Upstream product

1403-96-9Downstream Products

1403-96-9Related news

Structural characterization of microcin (cas 1403-96-9) E492 amyloid formation: Identification of the precursors09/10/2019

Microcin E492 is a low-molecular weight, channel-forming bacteriotoxin that generates amyloid structures. Using electron microscopy and image processing techniques several structural conformations can be observed. Prior to the conditions that induce amyloid formation and at its initial stage, mi...detailed

ArticleArchitecture of microcin (cas 1403-96-9) B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison09/07/2019

SummaryThe introduction of azole heterocycles into a peptide backbone is the principal step in the biosynthesis of numerous compounds with therapeutic potential. One of them is microcin B17, a bacterial topoisomerase inhibitor whose activity depends on the conversion of selected serine and cyste...detailed

The antimicrobial peptide microcin (cas 1403-96-9) J25 stabilizes the gel phase of bacterial model membranes09/06/2019

The bacterial membrane interaction of the antimicrobial peptide microcin J25 was studied with the probe-free techniques Langmuir monolayers and infrared spectroscopy. Membrane model systems composed by phosphatidylethanolamine:phosphatidylglycerol 7:3, which mimic the cytoplasmic membrane of Gra...detailed

Cytochromes bd-I and bo3 are essential for the bactericidal effect of microcin (cas 1403-96-9) J25 on Escherichia coli cells09/04/2019

Microcin J25 has two targets in sensitive bacteria, the RNA polymerase, and the respiratory chain through inhibition of cellular respiration. In this work, the effect of microcin J25 in E. coli mutants that lack the terminal oxidases cytochrome bd-I and cytochrome bo3 was analyzed. The mutant st...detailed

ReviewThe Microbial Toxin microcin (cas 1403-96-9) B17: Prospects for the Development of New Antibacterial Agents09/03/2019

Microcin B17 (MccB17) is an antibacterial peptide produced by strains of Escherichia coli harboring the plasmid-borne mccB17 operon. MccB17 possesses many notable features. It is able to stabilize the transient DNA gyrase–DNA cleavage complex, a very efficient mode of action shared with the hig...detailed

Chapter Forty - microcin (cas 1403-96-9) SF60809/02/2019

The first total synthesis of the aquatic peptide microcin SF608 isolated from the cyanobacterium Microcystis aeruginosa is outlined in this chapter. The peptide natural product has been reported to possess potent serine protease trypsin inhibitory activity.detailed

Multifaceted ABC transporters associated to microcin (cas 1403-96-9) and bacteriocin export09/01/2019

Microcins and bacteriocins are ribosomally-synthesized defence peptides produced by Gram-negative and -positive bacteria to target competitors in their niche. Some of them carry posttranslational modifications established by dedicated enzymes. To protect themselves from their own toxic peptides,...detailed

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