1403234-75-2Relevant academic research and scientific papers
Absolute configuration assignment of 3-indolylacetate esters
Vazquez-Arredondo, Rosa M.,Suarez-Castillo, Oscar R.,Melendez-Rodriguez, Myriam,Sanchez-Zavala, Maricruz,Cano-Escudero, Indira C.,Bautista-Hernandez, Claudia I.,Cruz-Borbolla, Julian,Morales-Rios, Martha S.,Joseph-Nathan, Pedro
, p. 1279 - 1293 (2012/11/07)
Herein we describe a straightforward method for the determination of the absolute configuration of 3-indolyl(bromo)acetate 7, 3-indolyl(alkoxy)acetates 8a-f and 3-indolyl(amino)acetate 8g, based on 1H NMR spectral analysis. The conformational preferences for two diastereomeric esters were calculated by DFT, which matched very well with the experimental results. X-ray diffraction analysis allowed us to validate the methodology, and independent absolute configuration evidence was obtained by vibrational circular dichroism.
