1403324-90-2

Basic information

• Product Name: (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate
• Synonyms: (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate
• CAS NO: 1403324-90-2
• Molecular Weight: 379.238
• Mol File: 1403324-90-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate(1403324-90-2)
• EPA Substance Registry System: (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate(1403324-90-2)

Safety Data

• Hazardous Substances Data: 1403324-90-2(Hazardous Substances Data)

Upstream product

• 889362-93-0 (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-ylcarbamate 
• 6485-58-1 iodoethane-d5 

Downstream Products

• 1403324-91-3 (S)-benzyl 5-amino-2,3-dihydro-1H-inden-2-yl([²H₅]ethyl)carbamate 
• 1403324-92-4 (R)-benzyl 2-benzamido-6,7-dihydro-5H-indeno[5,6-d]thiazol-6-yl([²H₅]ethyl)carbamate 
• 1403324-93-5 (R)-N-(6-([²H₅]ethylamino)-6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzamide 

Relevant articles and documents

Preparation of two D2 partial agonists in C-14 and stable isotope labeled forms

In support of a program to develop a treatment for diseases resulting from an imbalance in dopamine levels, two drug candidates, 1 and 2, were prepared in stable isotope and C-14 labeled forms. Both compounds contained an aminothiazole ring, and the C-14 label was introduced into the ring using KS14CN. However, the use of KS14CN to form [14C]-2 gave poor results; therefore, benzoyl [14C]isothiocyanate was used instead, which led to a much improved yield. The stable isotope labeled forms were prepared with the label in the side chain from [2H5]ethyl iodide for [2H5]-1 and from 1-[13C]methyl [15N2]pyrazole[13C]carboxaldehyde, which was prepared in turn from [carbonyl-13C]DMF, [15N 2]hydrazine sulfate, and [13C]methyliodide for [ 13C2, 15N2]-2. Copyright