1403378-82-4Relevant articles and documents
GK and PPAR dual agonist activity containing dimethyl aryl urea derivatives
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Paragraph 0289; 0291-0292, (2016/10/20)
The invention discloses a novel arylurea derivative, its preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an arylurea derivative as shown in the general formula I, its medicinal salt, a preparation method thereof, a composition containing one or more of the compounds, and an application of the compounds in treatment of glucokinase and peroxisome proliferator-activated receptor related diseases such as diabetes, obesity and the like.
Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ
Li, Yongqiang,Tian, Kang,Qin, Aifang,Zhang, Lijian,Huo, Lianchao,Lei, Lei,Shen, Zhufang,Song, Hongrui,Feng, Zhiqiang
, p. 182 - 192 (2014/03/21)
Motivated by the discovery of a potential ligand that activates both glucokinase (GK) and perioxisome proliferator-activated receptor-γ (PPARγ), this work presents the rational design and synthesis of a series of novel urea derivatives as potent dual-targ
