1403459-91-5Relevant academic research and scientific papers
Synthesis of thiophenes in a deep eutectic solvent: heterocyclodehydration and iodocyclization of 1-mercapto-3-yn-2-ols in a choline chloride/glycerol medium
Mancuso, Raffaella,Maner, Asif,Cicco, Luciana,Perna, Filippo M.,Capriati, Vito,Gabriele, Bartolo
, p. 4239 - 4244 (2016)
The heterocyclodehydration and iodocyclization of readily available 1-mercapto-3-yn-2-ols has been performed in a deep eutectic solvent (DES), that is, ChCl/Gly (1:2 molar ratio; ChCl=choline chloride, Gly=glycerol), as a non-conventional green solvent. T
An iodocyclization approach to substituted 3-iodothiophenes
Gabriele, Bartolo,Mancuso, Raffaella,Salerno, Giuseppe,Larock, Richard C.
, p. 7640 - 7645 (2012/11/07)
A novel approach to 3-iodothiophenes by direct iodocyclization of alkynylthiol derivatives is presented. A variety of 1-mercapto-3-yn-2-ols 5 (readily available from alkynylation of the corresponding alpha-mercapto ketones or alpha-mercapto esters) were smoothly converted into the corresponding 3-iodothiophene derivatives 6 in good yields by reaction with molecular iodine in the presence of NaHCO3 at room temperature in MeCN as the solvent.
