1403495-75-9Relevant academic research and scientific papers
Skeletal hybridization and PfRIO-2 kinase modeling for synthesis of α-pyrone analogs as anti-malarial agent
Parveen, Afsana,Chakraborty, Arnish,Konreddy, Ananda Kumar,Chakravarty, Harapriya,Sharon, Ashoke,Trivedi, Vishal,Bal, Chandralata
, p. 607 - 612 (2013)
The pharmacophoric hybridization and computational design approach were applied to generate a novel series of α-pyrone analogs as plausible anti-malarial lead candidate. A putative active site in flexible loop close to wing-helix domain of PfRIO2 kinase was explored computationally to understand the molecular basis of ligand binding. All the synthesized molecules (3a-g) exhibited in vitro antimalarial activity. Oxidative stress induced by 3a-d were calculated and found to be significantly higher in case of 3b. Therefore, 3b, which shown most significant result was identified as promising lead for further SAR study to develop potent anti-malarials.
Synthesis and anti-HCV activity of 4-hydroxyamino α-pyranone carboxamide analogues
Konreddy, Ananda Kumar,Toyama, Massaki,Ito, Wataru,Bal, Chandralata,Baba, Masanori,Sharon, Ashoke
, p. 259 - 263 (2014/04/03)
High genetic variability in hepatitis C virus (HCV), emergence of drug resistant viruses and side effects demand the requirement for development of new scaffolds to show an alternate mechanism. Herein, we report discovery of new scaffold I based on 4-hydr
Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent
Karampuri, Srinivas,Bag, Paromita,Yasmin, Sabina,Chouhan, Devendra Kumar,Bal, Chandralata,Mitra, Debashis,Chattopadhyay, Debprasad,Sharon, Ashoke
, p. 6261 - 6266 (2012/10/29)
Several options for treating Herpes Simplex Virus type 1 and type 2 are available. However, non-specific inhibition and drug resistance warrants the discovery of new anti-herpetic compounds with better therapeutic profile or different mode of action. The
