1403497-64-2Relevant academic research and scientific papers
Chemoselective Radiosyntheses of Electron-Rich [18F]Fluoroarenes from Aryl(2,4,6-trimethoxyphenyl)iodonium Tosylates
Kwon, Young-Do,Son, Jeongmin,Chun, Joong-Hyun
, p. 3678 - 3686 (2019/03/11)
Hypervalent diaryliodonium salts have been used to produce various [18F]fluoroarenes. The iodonium salt approach as a labeling precursor has been established to equally afford complex 18F-fluorinated molecules. Because of the inheren
Catalyst-Free Aromatic Radiofluorination via Oxidized Iodoarene Precursors
Kwon, Young-Do,Son, Jeongmin,Chun, Joong-Hyun
, p. 7902 - 7906 (2019/01/04)
Oxidized iodoarenes (OIAs), prepared via mCPBA-mediated oxidation, have been demonstrated as versatile precursors for the synthesis of [18F]fluoroarenes in the absence of catalysts. OIAs have been identified as intermediates in single-pot syntheses of iodonium salts and ylides but have never been recognized as radiofluorination precursors. Here, the isolated OIAs were used without any catalysts to produce functionalized [18F]fluoroarenes, regardless of the electronic nature of the arenes. This method was also applied to the production of radiolabeling synthons for use as aromatic 18F-labeled building blocks.
Single-step radiosynthesis of "18F-labeled click synthons" from azide-functionalized diaryliodonium salts
Chun, Joong-Hyun,Pike, Victor W.
, p. 4541 - 4547,7 (2020/08/31)
Positron emission tomography (PET) is an increasingly important biomedical imaging technique that relies on the development of radiotracers labeled with positron emitters to achieve biochemical specificity. Fluorine-18 (t 1/2 = 109.7 min) is an
