14035-08-6Relevant academic research and scientific papers
Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids
Abdu-Allah, Hajjaj H.M.,Abdelmoez, Alshaimaa A.B.,Tarazi, Hamadeh,El-Shorbagi, Abdel-Nasser A.,El-Awady, Raafat
, (2020)
Eicosanoids like leukotrienes and prostaglandins that produced within the arachidonic acid cascade are involved in the pathogenesis of pain, acute and chronic inflammatory diseases. A promising approach for an effective anti-inflammatory therapy is the de
P-aminosalicylic acid fluoroquinolone derivative as well as intermediate, preparation method and application thereof
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Paragraph 0053; 0057-0059, (2021/01/24)
The invention discloses a p-aminosalicylic acid fluoroquinolone derivative and an intermediate, a preparation method and application thereof, and belongs to the technical field of drug synthesis. Thestructural formula of the p-aminosalicylic acid fluoroquinolone derivative is shown in the specification. In-vitro activity determination results show that part of fluoroquinolone aminosalicylate derivatives (compounds for short) and intermediates have inhibition effects on mycobacterium smegmatis; the compounds and intermediates have good inhibition activity on common pathogenic bacteria as a whole; most compounds and intermediates have better antibacterial activity on pichia pastoris as a whole; part of the compounds have good inhibitory activity on citrus canker pathogens. The p-aminosalicylic acid fluoroquinolone derivative and the intermediate thereof have potential application prospects in the fields of tuberculosis resistance, bacteria resistance, fungus resistance and citrus pathogen resistance.
para-aminosalicylic acid azole derivative as well as preparation method and application thereof
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Paragraph 0051; 0055-0057, (2020/12/15)
The invention discloses a para-aminosalicylic acid azole derivative as well as a preparation method and application thereof, and belongs to the technical field of drug synthesis. The structural formula of the para-aminosalicylic acid azole derivative is shown in the specifications. An antibacterial activity determination result shows that the para-aminosalicylic acid azole derivative disclosed bythe invention has good inhibition activity on common pathogenic bacteria as a whole, and the antibacterial activity of part of molecules on pichia pastoris is stronger than or equal to that of a positive drug, fluconazole; all the molecules have good inhibitory activity on colletotrichum gloeosporioides, part of the molecules have the inhibitory activity equal to or higher than that of positive control prochloraz, and most of the molecules have a good inhibitory effect on citrus canker pathogens. An anti-tumor cell activity determination result shows that the para-aminosalicylic acid azole derivative disclosed by the invention has an inhibition effect on the three kinds of tumor cells. The para-aminosalicylic acid azole derivative disclosed by the invention has a potential application prospect in the fields of bacterium resistance, fungus resistance, citrus pathogen resistance and tumor resistance.
