1403580-74-4

Upstream product

• 133992-60-6 1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)ethan-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 622-79-7 benzyl azide 
• 123-54-6 acetylacetone 

Downstream Products

• 1416209-24-9 C₂₁H₂₁N₅OS 
• 1557968-51-0 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(4-methoxyphenyl)pyrimidin-2-amine 

Relevant academic research and scientific papers

A facile synthesis of 1,2,3-triazolyl indole hybrids via SbCl3-catalysed Michael addition of indoles to 1,2,3-triazolyl chalcones

An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a-u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction time. Subsequently, SbCl3 catalysed Michael addition of indoles to the chalcones afford 1,2,3-triazolyl indole hybrids (5a-l) in excellent yields. Indian Academy of Sciences.

Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2- thione hybrids - Highly potent antibacterial agents

An elegant and efficient synthesis of hitherto novel 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids has been accomplished for the first time in a green solvent viz. water. The hybrid molecules exhibit significant antibacterial activity when screened against four human pathogens viz. Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. In comparison to the commercially marketed tetracycline, some of them were equally potent and a few more potent.