1403620-26-7Relevant academic research and scientific papers
A catalytic asymmetric ring-expansion reaction of isatins and α-alkyl-α-diazoesters: Highly efficient synthesis of functionalized 2-quinolone derivatives
Li, Wei,Liu, Xiaohua,Hao, Xiaoyu,Cai, Yunfei,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 8644 - 8647 (2012/09/22)
Asymmetric expansion: A catalytic asymmetric ring-expansion reaction of the title compounds occurs in the presence of a Sc(OTf)3 catalyst bearing an N,N?-dioxide-based ligand. Highly functionalized 2-quinolone derivatives containing a chiral C4-quaternary stereocenter were obtained in high yields and high levels of selectivity under mild reaction conditions (see scheme; Tf=trifluoromethanesulfonyl).
