874162-66-0Relevant academic research and scientific papers
Trifluoromethylthiolation and Trifluoromethylselenolation of α-Diazo Esters Catalyzed by Copper
Matheis, Christian,Krause, Thilo,Bragoni, Valentina,Goossen, Lukas J.
, p. 12270 - 12273 (2016/08/24)
α-Diazo esters are smoothly converted into the corresponding trifluoromethyl thio- or selenoethers by reaction with Me4NSCF3or Me4NSeCF3, respectively, in the presence of catalytic amounts of copper thiocyanate. This straightforward method gives high yields under neutral conditions at room temperature and is applicable to a wide range of functionalized molecules, including diverse α-amino acid derivatives. It is well-suited for the late-stage introduction of trifluoromethylthio or -seleno groups into drug-like molecules.
Exploring the reaction of iodine with α-diazo esters
Werardo, Giancarlo,Geatti, Paola,Gambi, Alberto
experimental part, p. 24 - 30 (2009/07/26)
In this paper we describe the unprecedented reaction between a-diazo esters 1 and iodine. The reaction, carried out in the presence of aqueous NaHCO 3, afforded the Z-isomer of the corresponding unsaturated-2-iodo ester 8, The configuration of
Polymer-bound diazonium salts for the synthesis of diazoacetic esters
Schroen, Maarten,Br?se, Stefan
, p. 12186 - 12192 (2007/10/03)
Starting from Merrifield resin, various polymer-bound diazonium salts were prepared. Upon treatment with amino acid esters, resulting the appropriate triazenes, the corresponding diazoacetic esters were formed by basic cleavage. Scope and limitation of th
