1403649-68-2Relevant academic research and scientific papers
Organocatalytic asymmetric direct Csp3 -H functionalization of ethers: A highly efficient approach to chiral spiroethers
Jiao, Zhi-Wei,Zhang, Shu-Yu,He, Chuan,Tu, Yong-Qiang,Wang, Shao-Hua,Zhang, Fu-Min,Zhang, Yong-Qiang,Li, Hui
, p. 8811 - 8815 (2012/10/08)
Spiro compounds: An organocatalytic asymmetric method for the C sp 3=H functionalization of the α position of racemic cyclic ethers has been developed. The transformation, mediated by catalytic amounts of an imidazolidinone and strong acid, involves a tandem 1,5-hydride transfer/cyclization and provides access to a structurally diverse series of chiral spiroethers with high levels of enantioselectivity (see scheme). Copyright
