1403656-57-4Relevant academic research and scientific papers
On the mechanism of the direct acid catalyzed formation of 2,3-disubstituted imidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones. Concurrence between ketimine and Ortoleva-King type reaction intermediated transformations
Kurteva, Vanya B.,Lubenov, Lubomir A.,Antonova, Daniela V.
, p. 175 - 184 (2014/01/06)
Direct acid catalyzed formation of 2,3-disubstituted imidazo[1,2-a] pyridines from 2-aminopyridines and acetophenones was studied in order to gain insight into the reaction mechanism. The formation of differently substituted products was explained by a concurrent ketimine and Ortoleva-King type reaction intermediated transformations. The dependence of the reaction output on the catalyst used and on acetophenone and pyridine substituents was discussed.
Fast and efficient direct conversion of 2-aminopyridine into 2,3-disubstituted imidazo[1,2-a]pyridines
Kurteva, Vanya B.,Lubenov, Lubomir A.,Nedeltcheva, Daniela V.,Nikolova, Rositsa P.,Shivachev, Boris L.
, p. 282 - 294 (2012/11/07)
A direct conversion of 2-aminopyridine into 2,3-disubstituted imidazo[1,2-a]pyridines was studied. A series of products was obtained in an efficient, simple and fast protocol. The scope and limitation of the transformation are also studied and was found that its effectiveness and the type of the substituent at 3-position, 3-(1-arylethane) and/or 3-(1-arylethene), is strongly dependent both on the catalyst and on the ketone aromatic substituent. The structures of the products were assigned by 1D and 2D NMR spectra and confirmed by X-ray analyses of selected samples. ARKAT-USA, Inc.
