1403665-32-6

Basic information

• Product Name: 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate
• CAS NO: 1403665-32-6
• Molecular Weight: 325.318
• Mol File: 1403665-32-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate(1403665-32-6)
• EPA Substance Registry System: 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate(1403665-32-6)

Safety Data

• Hazardous Substances Data: 1403665-32-6(Hazardous Substances Data)

Upstream product

• 1403665-31-5 dimethyl 2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 885117-62-4 methyl 3-hydroxy-3-(2-methoxy-2-oxoethyl)-2-oxoindoline-1-carboxylate 
• 64-17-5 ethanol 

Downstream Products

• 1403665-38-2 methyl 4-(2-methoxy-2-oxoethyl)-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-4-carboxylate 
• 39497-01-3 methyl 1,2-dihydro-2-oxoquinoline-4-carboxylate 
• 1403665-36-0 diethyl 2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 1403665-39-3 ethyl 4-(2-ethoxy-2-oxoethyl)-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-4-carboxylate 
• 1403665-42-8 methyl 3-(2-ethoxy-2-oxoethyl)-3-hydroxy-2-oxoindoline-1-carboxylate 

Relevant articles and documents

Microwave-assisted synthesis of 3,1-benzoxazin-2-ones from 3-hydroxyoxindoles

A general protocol for the synthesis of 3,1-benzoxazin-2-ones 18 from 3-hydroxyoxindoles 16 in a two steps sequence through phenylsuccinates or phenylpropionates 17 is described. Best reaction conditions for ring opening of 16 to succinates or propionates 17 were achieved using alcohol/silica gel, while cyclization of 17 to benzoxazinones 18 was easily done with HCl/alcohol. It was also found that 17 and 18 can be transesterified using HCl/alcohol. Most transformations were carried out by traditional heating and by microwave (MW) irradiation to accelerate reaction rates.