39497-01-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester is used as an active pharmaceutical ingredient for the development of drugs with antifungal and antibacterial properties. Its potential use in the treatment of various diseases, including cancer and infectious diseases, makes it a valuable compound in the pharmaceutical industry.
Used in Anticancer Applications:
In the field of oncology, 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester is used as a potential therapeutic agent for the treatment of various types of cancer. Its antioxidant and anti-inflammatory properties contribute to its potential as a cancer treatment, as it may help to reduce inflammation and oxidative stress associated with cancer progression.
Used in Antimicrobial Applications:
4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester is used as an antimicrobial agent, particularly against fungi and bacteria. Its potential use in the treatment of infectious diseases highlights its importance in the development of new antimicrobial drugs to combat drug-resistant pathogens.
Used in Research:
In the field of scientific research, 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester is used as a valuable compound for studying its potential applications in medicine. Its antioxidant and anti-inflammatory properties make it an interesting subject for research into the development of new therapeutic agents for various diseases and conditions.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester, various drug delivery systems have been developed. These systems aim to improve the compound's delivery to target tissues and cells, increasing its therapeutic potential and reducing potential side effects.

InChI:InChI=1/C11H9NO3/c1-15-11(14)8-6-10(13)12-9-5-3-2-4-7(8)9/h2-6H,1H3,(H,12,13)

Upstream product

• 21233-61-4 quinoline-4-carboxylic acid methyl ester 
• 15733-89-8 2-hydroxyquinoline-4-carboxylic acid 
• 144-55-8 sodium hydrogencarbonate 
• 74-88-4 methyl iodide 
• 15733-89-8 2-quinolone-4-carboxylic acid 
• 67-56-1 methanol 
• 141-82-2 malonic acid 
• 91-56-5 indole-2,3-dione 
• 1403665-32-6 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 1403665-31-5 dimethyl 2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 885117-62-4 methyl 3-hydroxy-3-(2-methoxy-2-oxoethyl)-2-oxoindoline-1-carboxylate 
• 186581-53-3 diazomethane 

Downstream Products

• 260972-83-6 α,α-Diphenyl-2-hydroxy-4-quinolinemethanol 
• 1174281-19-6 methyl 2-(tosyloxy)quinoline-4-carboxylate 
• 41874-24-2 2-oxo-1,2-dihydroquinoline-4-carbohydrazide 
• 103502-48-3 2-bromo-quinoline-4-carboxylic acid methyl ester 
• 62482-26-2 methyl 2-chloroquinoline-4-carboxylate 
• 1354965-42-6 2-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline-4-carboxylic acid 
• 1354965-40-4 methyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline-4-carboxylate 
• 107520-08-1 2-hydroxy-4-quinoline 

Relevant academic research and scientific papers

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our early efforts at optimization of the quinoline core, the imidazole and the semithiocarbazone moiety. Most potency gains came from substitution around the 6- and 7-positions of the quinoline ring. Replacement of the semithiocarbazone with a semicarbazone decreased potency but led to some measurable exposure.

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Design, synthesis and evaluation of a new calix[4]arene based molecular receptor for multiple ion selectivity

The hydrophobic and conformational motifs of calix[4]arene stereostructure and plausible binding characteristics of heterocyclic 2-oxo-1,2-dihydroquinoline-4-carbohydrazide have been deployed for the design and synthesis of a new molecular receptor, 4 for multi-ion recognition. The target molecule was synthesized through the condensation of 3 with 2-oxo-1,2-dihydroquinoline-4-carbohydrazide (6) in refluxing ethanol. It has been determined that 4 exhibits an exclusive color change from colorless to yellow as well as a 5.5 fold increase in the fluorescence intensity upon interaction with fluoride due to formation of multiple hydrogen bonds. Consequent to fluoride induced deprotonation, 4 displays a dual selectivity for Cu2+ and Ni2+ ions from amongst plethora of investigated cations.

Microwave-assisted synthesis of 3,1-benzoxazin-2-ones from 3-hydroxyoxindoles

A general protocol for the synthesis of 3,1-benzoxazin-2-ones 18 from 3-hydroxyoxindoles 16 in a two steps sequence through phenylsuccinates or phenylpropionates 17 is described. Best reaction conditions for ring opening of 16 to succinates or propionates 17 were achieved using alcohol/silica gel, while cyclization of 17 to benzoxazinones 18 was easily done with HCl/alcohol. It was also found that 17 and 18 can be transesterified using HCl/alcohol. Most transformations were carried out by traditional heating and by microwave (MW) irradiation to accelerate reaction rates.

COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

Heteroaromatic tosylates as electrophiles in regioselective Mizoroki-Heck-coupling reactions with electron-rich olefins

Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki-Heck-coupling reactions to electron-rich olefins with complete aregioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki-Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the synthetic utility of the functionalized α-heteroarylvinyl amides was established providing straightforward access to highly functionalized heteroaromatic compounds including chiral benzylic amide derivatives.

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.

NOVEL CYANOGUANIDINE COMPOUNDS

Novel pyridyl cyanoguanidien compounds of general formula I (I) wherein R1, X, R2 and R3 are as defined herein, exhibit a high antiproliferative activity and may be used in the treatment of hyperproliferative and neoplastic diseases.

Antiinflammation agents

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

Use of imidazo?1,5-a!quinolones as neuroprotective agents

The imidazo?1,5-a!quinolines (I) are useful in treating neurological diseases/conditions or chronic neurodegenerative diseases/conditions.