39497-01-3

Basic information

• Product Name: 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester
• Synonyms: 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester;Methyl 2-oxo-1,2-dihydroquinoline-4-carboxylate
• CAS NO: 39497-01-3
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19406
• Mol File: 39497-01-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 415.2°C at 760 mmHg
• Flash Point: 204.9°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 4.2E-07mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(39497-01-3)
• EPA Substance Registry System: 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(39497-01-3)

Safety Data

• Hazardous Substances Data: 39497-01-3(Hazardous Substances Data)

Usage

General Description

4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester is a chemical compound that is commonly used in the pharmaceutical industry. It is a methyl ester derivative of 4-Quinolinecarboxylic acid, which is known for its potential antifungal and antibacterial properties. This chemical has also been studied for its potential use in the treatment of various diseases, including cancer and infectious diseases. Additionally, 4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester has been found to have antioxidant and anti-inflammatory properties, making it a versatile compound with many potential applications in medicine and research.

InChI:InChI=1/C11H9NO3/c1-15-11(14)8-6-10(13)12-9-5-3-2-4-7(8)9/h2-6H,1H3,(H,12,13)

Upstream product

• 67-56-1 methanol 
• 141-82-2 malonic acid 
• 91-56-5 indole-2,3-dione 
• 15733-89-8 2-quinolone-4-carboxylic acid 
• 1403665-32-6 1-ethyl 4-methyl-2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 1403665-31-5 dimethyl 2-hydroxy-2-(2-(methoxycarbonylamino)phenyl)succinate 
• 885117-62-4 methyl 3-hydroxy-3-(2-methoxy-2-oxoethyl)-2-oxoindoline-1-carboxylate 
• 74-88-4 methyl iodide 
• 15733-89-8 2-hydroxyquinoline-4-carboxylic acid 
• 144-55-8 sodium hydrogencarbonate 
• 186581-53-3 diazomethane 
• 21233-61-4 quinoline-4-carboxylic acid methyl ester 

Downstream Products

• 260972-83-6 α,α-Diphenyl-2-hydroxy-4-quinolinemethanol 
• 41874-24-2 2-oxo-1,2-dihydroquinoline-4-carbohydrazide 
• 1354965-42-6 2-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline-4-carboxylic acid 
• 1354965-40-4 methyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline-4-carboxylate 
• 103502-48-3 2-bromo-quinoline-4-carboxylic acid methyl ester 
• 1174281-19-6 methyl 2-(tosyloxy)quinoline-4-carboxylate 
• 62482-26-2 methyl 2-chloroquinoline-4-carboxylate 
• 107520-08-1 2-hydroxy-4-quinoline 

Relevant articles and documents

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our early efforts at optimization of the quinoline core, the imidazole and the semithiocarbazone moiety. Most potency gains came from substitution around the 6- and 7-positions of the quinoline ring. Replacement of the semithiocarbazone with a semicarbazone decreased potency but led to some measurable exposure.

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Microwave-assisted synthesis of 3,1-benzoxazin-2-ones from 3-hydroxyoxindoles

A general protocol for the synthesis of 3,1-benzoxazin-2-ones 18 from 3-hydroxyoxindoles 16 in a two steps sequence through phenylsuccinates or phenylpropionates 17 is described. Best reaction conditions for ring opening of 16 to succinates or propionates 17 were achieved using alcohol/silica gel, while cyclization of 17 to benzoxazinones 18 was easily done with HCl/alcohol. It was also found that 17 and 18 can be transesterified using HCl/alcohol. Most transformations were carried out by traditional heating and by microwave (MW) irradiation to accelerate reaction rates.