1403679-86-6

Upstream product

• 26107-79-9 methyl 2-chloro-5-trifluoromethyl-benzoate 
• 75-05-8 acetonitrile 

Downstream Products

• 1403679-87-7 3-[2-chloro-5-(trifluoromethyl)phenyl]-3-[(2,2-diethoxyethyl)amino]prop-2-enenitrile 
• 1403679-88-8 2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile 
• 1403679-33-3 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide 
• 1403680-23-8 5-acetyl-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile 
• 1403680-24-9 2-[2-chloro-5-(trifluoromethyl)phenyl]-5-((E)-3-dimethylamino-acryloyl)-1H-pyrrole-3-carbonitrile 
• 1403680-25-0 5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING CANCER

Compounds useful as modulators of AhR, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate AhR-mediated disorders such as cancers and inflammatory diseases are provided.

SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS

The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.