140384-89-0Relevant academic research and scientific papers
Nitrile oxides in medicinal chemistry. 5. Lipase PS-catalyzed resolution of a set of heterocyclic derivatives
Carrea,De Amici,De Micheli,Liverani,Carnielli,Riva
, p. 1063 - 1072 (2007/10/02)
Lipase from Pseudomonas cepacia (lipase PS) catalyzed the hydrolysis of a series of butyrates of racemic primary alcohols carrying a Δ2-isoxazoline or an isoxazolidin-3-one nucleus. Within this set of compounds, the enantiopreference of the cat
Nitrile Oxides in Medicinal Chemistry. 4. Chemoenzymatic Synthesis of Chiral Heterocyclic Derivatives
Amici, Marco De,Magri, Paolo,Micheli, Carlo De,Cateni, Francesca,Bovara, Roberto,et al.
, p. 2825 - 2829 (2007/10/02)
The two enantiomers of 3-bromo-5-(hydroxymethyl)-Δ2-isoxazoline (1) and 2-phenyl-5-(hydroxymethyl)-isoxazolidin-3-one (9) have been prepared in enantiomeric excess higher than 90percent by hydrolysis of the corresponding butyrates under the cat
