1403893-75-3Relevant academic research and scientific papers
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
Jiao, Xianyun,Kopecky, David J.,Liu, Jinsong,Liu, Jinqian,Jaen, Juan C.,Cardozo, Mario G.,Sharma, Rajiv,Walker, Nigel,Wesche, Holger,Li, Shyun,Farrelly, Ellyn,Xiao, Shou-Hua,Wang, Zhulun,Kayser, Frank
, p. 6212 - 6217 (2012/10/29)
Two classes of ACK1 inhibitors, 4,5,6-trisubstituted furo[2,3-d]pyrimidin4- amines and 4,5,6-trisubstituted 7H-pyrrolo[2,3-d]pyrimidin-4-amines, were discovered and evaluated as ACK1 inhibitors. Further structural refinement led to the identification of potent and selective dithiolane inhibitor 37.
