873078-75-2 Usage
Chemical structure
1H-Pyrrolo[2,3-d]pyrimidin-4-amine with a 5-phenyl-6-(triethylsilyl) substitution.
5-Phenyl
A phenyl group (a carbon-based ring with delocalized electrons) attached to the pyrimidine core.
6-(Triethylsilyl)
A triethylsilyl group (silyl group with three ethyl substituents) attached to the pyrimidine core.
Aromatic and hydrophobic properties
Influenced by the presence of the phenyl group.
Applications
Organic synthesis, pharmaceuticals, agrochemicals, and materials science.
Versatility
Acts as a building block and intermediate in organic synthesis with potential applications in drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 873078-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,0,7 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 873078-75:
(8*8)+(7*7)+(6*3)+(5*0)+(4*7)+(3*8)+(2*7)+(1*5)=202
202 % 10 = 2
So 873078-75-2 is a valid CAS Registry Number.
873078-75-2Relevant academic research and scientific papers
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
Jiao, Xianyun,Kopecky, David J.,Liu, Jinsong,Liu, Jinqian,Jaen, Juan C.,Cardozo, Mario G.,Sharma, Rajiv,Walker, Nigel,Wesche, Holger,Li, Shyun,Farrelly, Ellyn,Xiao, Shou-Hua,Wang, Zhulun,Kayser, Frank
, p. 6212 - 6217 (2012/10/29)
Two classes of ACK1 inhibitors, 4,5,6-trisubstituted furo[2,3-d]pyrimidin4- amines and 4,5,6-trisubstituted 7H-pyrrolo[2,3-d]pyrimidin-4-amines, were discovered and evaluated as ACK1 inhibitors. Further structural refinement led to the identification of potent and selective dithiolane inhibitor 37.
PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY
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Page/Page column 38, (2010/02/15)
Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided her
