1403894-06-3

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 335654-06-3 2-chloro-7H-pyrrolo[2,3-d]pyrimidine 
• 948571-47-9 2-(4-amino-1H-pyrazol-1-yl)ethan-1-ol 
• 1403894-25-6 2-chloro-7-(2-fluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

(7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINE COMPOUNDS AS JAK3 INHIBITORS

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, and Z1 to Z3 have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.