1403898-63-4Relevant academic research and scientific papers
PYRIDO[2,3-B] [1,4] OXAZINES OR TETRAHYDROPYRIDO[2,3-B][1,4] OXAZEPINES AS IAP ANTAGONISTS
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Page/Page column 36, (2021/12/31)
Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b][1,4] oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the use of such compounds for treating proliferative disease such as cancer.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP
Chessari, Gianni,Buck, Ildiko M.,Day, James E. H.,Day, Philip J.,Iqbal, Aman,Johnson, Christopher N.,Lewis, Edward J.,Martins, Vanessa,Miller, Darcey,Reader, Michael,Rees, David C.,Rich, Sharna J.,Tamanini, Emiliano,Vitorino, Marc,Ward, George A.,Williams, Pamela A.,Williams, Glyn,Wilsher, Nicola E.,Woolford, Alison J.-A.
supporting information, p. 6574 - 6588 (2015/09/07)
(Figure Presented) Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis and pro-survival signaling pathways whose deregulation is often associated with tumor genesis and tumor growth. IAPs have been proposed as targets for anticanc
BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
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Page/Page column 123, (2014/05/07)
The invention relates to new bicyclic heterocycle compounds of formula (I):,to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
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Page/Page column 120, (2012/11/07)
The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
