1403898-62-3

Basic information

• Product Name: (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione
• CAS NO: 1403898-62-3
• Molecular Weight: 158.157
• Mol File: 1403898-62-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione(1403898-62-3)
• EPA Substance Registry System: (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione(1403898-62-3)

Safety Data

• Hazardous Substances Data: 1403898-62-3(Hazardous Substances Data)

Usage

Description

(3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione is a chemical compound characterized by a piperazine ring, which is a heterocyclic organic compound commonly utilized in the synthesis of pharmaceuticals and agrochemicals. This specific compound features a hydroxymethyl and a methyl substituent, with the hydroxymethyl group providing a hydroxyl functional group that can engage in various chemical reactions. (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione's stereochemistry, denoted by the (3S,6R) configuration, significantly influences its biological activity and potential applications. As a result, (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione holds promise for use in medicinal and chemical research and development.

Uses

Used in Pharmaceutical Synthesis:
(3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and functional groups make it a valuable building block for creating new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione is used as a starting material for the development of new pesticides and other agricultural chemicals. Its chemical properties and reactivity contribute to the creation of innovative products designed to improve crop protection and yield.
Used in Organic Synthesis:
(3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione is employed as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications. Its hydroxymethyl group enables it to participate in various chemical reactions, making it a valuable asset in the development of new materials and compounds.
Used in Research and Development:
(3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione is also utilized in research and development settings, where its unique properties and reactivity are explored for potential applications in various fields. The specific stereochemistry of (3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione makes it an interesting subject for studying the effects of stereochemistry on biological activity and chemical behavior.

Upstream product

• 1403898-61-2 (R)-2-((S)-2-benzyloxycarbonylamino-3-hydroxy-propionyl-amino)propionic acid methyl ester 

Downstream Products

• 1403898-63-4 ((2R,5R)-5-methyl-piperazin-2-yl)-methanol hydrochloride 
• 2349395-78-2 1-tert-butyl 3-methyl (3R,6R)-6-methylpiperazine-1,3-dicarboxylate 
• 1403898-70-3 (2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester 
• 1604817-73-3 (2R,5S)-5-(2-cyanoimidazol-1-ylmethyl)-4-{2-[6-(4-fluorobenzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1403903-28-5 (2R,5R)-5-chloromethyl-4-{2-[6-(4-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1403903-27-4 (2R,5R)-4-{2-[6-(4-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-5-hydroxymethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1403902-55-5 (2R,5R)-4-benzyl-5-chloromethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1403901-32-5 (2R,5R)-4-benzyl-5-hydroxymethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1403898-64-5 (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Preparation method of chiral 1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate

The invention provides a preparation method of chiral 1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate, and particularly relates to a preparation method of (3R,6R) -1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate. The preparation method comprises the steps of taking Boc-D-alanine and L-serine methyl ester hydrochloride as initial raw materials, and preparing the chiral 1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate through condensation reaction, deamination protection, ring closing reaction, reduction reaction, amino protection, oxidation reaction, ring closing reactionand ring opening reaction. According to the preparation method provided by the invention, the Boc amino protective agent is used for protecting amino, so that the production cost is reduced, the rawmaterials are easy to obtain, the conditions are mild, the yield is relatively high, and the preparation method can be applied to large-scale industrial production.

CHEMICAL COMPOUNDS

The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY

The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.