14039-58-8

Upstream product

• 1761-56-4 2-[[(2-hydroxyphenyl)imino]methyl]phenol 
• 12775-96-1 copper 
• 95-55-6 2-amino-phenol 
• 90-02-8 salicylaldehyde 

Relevant academic research and scientific papers

Electrochemical synthesis and structural characterization of nickel(II) and copper(II) complexes of tridentate Schiff bases: molecular structureof the five-coordinated copper(II) complex: 1,10-phenanthroline {2-[(2- oxyphenyl)iminomethyl]phenolato}copper(II)

Electrochemical oxidation of metal anodes (copper and nickel) in acetonitrile solutions of Schiff bases (H2L) (synthesized from salicylaldehydesand 2-aminophenols) gave CuL and NiL complexes. When 1,10-phenanthrolin e (phen) or 2,2'-bipyridine (bipy) was adde to the electrolytic cell, the mixed complexes CuLL' and NiLL' (L'=phen or bipy) were obtained. The crystal structure of 1,10-phenanthroline {2-[(2-oxyphenyl)iminomethyl]phenolato}copper(II) was determined by X-ray diffraction. The structure consists of monomeric molecules in which the copper atom has a distorted square-pyramidal CuN3O2 kernel.

Inhibition of copper-mediated aggregation of human γD-crystallin by Schiff bases

Abstract: Protein aggregation, due to the imbalance in the concentration of Cu2+ and Zn2+ ions is found to be allied with various physiological disorders. Copper is known to promote the oxidative damage of β/γ-crystallins in aged eye lens and causes their aggregation leading to cataract. Therefore, synthesis of a small-molecule ‘chelator’ for Cu2+ with complementary antioxidant effect will find potential applications against aggregation of β/γ-crystallins. In this paper, we have reported the synthesis of different Schiff bases and studied their Cu2+ complexation ability (using UV–Vis, FT-IR and ESI-MS) and antioxidant activity. Further based on their copper complexation efficiency, Schiff bases were used to inhibit Cu2+-mediated aggregation of recombinant human γD-crystallin (HGD) and β/γ-crystallins (isolated from cataractous human eye lens). Among these synthesized molecules, compound 8 at a concentration of 100 μM had shown ~95% inhibition of copper (100?μM)-induced aggregation. Compound 8 also showed a positive cooperative effect at a concentration of 5–15 μM on the inhibitory activity of human αA-crystallin (HAA) during Cu2+-induced aggregation of HGD. It eventually inhibited the aggregation process by additional ~20%. However, ~50% inhibition of copper-mediated aggregation of β/γ-crystallins (isolated from cataractous human eye lens) was recorded by compound 8 (100 μM). Although the reductive aminated products of the imines showed better antioxidant activity due to their lower copper complexing ability, they were found to be non-effective against Cu2+-mediated aggregation of HGD. Graphical Abstract: [Figure not available: see fulltext.]