1403959-05-6Relevant articles and documents
Organocatalyzed Baylis-Hillman reaction: An enantioselective approach
Thorat, Prashant B.,Goswami, Santosh V.,Khade, Bhimrao C.,Bhusare, Sudhakar R.
, p. 1320 - 1325 (2012/11/06)
A convenient protocol has been developed for the synthesis of Baylis-Hillman adducts in the presence of a base and an organocatalyst. We have designed and synthesized organocatalysts based on hydrogen bonding using a pyrrolidine ring as the backbone and applied them to Baylis-Hillman transformations. This method provides products in good to high yields (73-90%) and with excellent enantiomeric excesses (up to 96%) and reasonable reaction times.