1404077-99-1

Basic information

• Product Name: C₁₄H₁₄O₃
• CAS NO: 1404077-99-1
• Molecular Weight: 230.263
• Mol File: 1404077-99-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₄O₃(1404077-99-1)
• EPA Substance Registry System: C₁₄H₁₄O₃(1404077-99-1)

Safety Data

• Hazardous Substances Data: 1404077-99-1(Hazardous Substances Data)

Upstream product

• 77758-51-1 methyl hex-5-ynoate 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1404078-03-0 C₁₈H₂₃NO₂ 

Relevant articles and documents

Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines

Iodonium compounds play a pivotal role in18F-fluorination of radiopharmaceuticals containing non-activated arenes. However, preparation of these species is limited to oxidation conditions or exchange with organometallics that are prepared from aryl halides. Herein we describe a novel “one-pot” process to assemble aryl(isoquinoline)iodonium salts in 40–94 % yields from mesoionic carbene silver complex and Aryl-I-Py2(OTf)2. The method is general, practical, and compatible with well-functionalized molecules as well as useful for the preparation of a wide range of18F-labeled isoquinolines resulting in up to 92 % radiochemical conversion. As proof of concept, a fluorinated isoquinoline alkaloid,18F-aspergillitine is prepared in 10 % isolated radiochemical yield from the corresponding phenyl(aspergillitine)iodonium salt.