1404079-95-3

Basic information

• Product Name: ethyl [4-phenyl-5-pyridin-4-yl-3-thioxo-2,4-dihydro-3H-1,2,4-triazol-2-yl]carboxylate
• Synonyms: ethyl [4-phenyl-5-pyridin-4-yl-3-thioxo-2,4-dihydro-3H-1,2,4-triazol-2-yl]carboxylate
• CAS NO: 1404079-95-3
• Molecular Weight: 326.379
• Mol File: 1404079-95-3.mol

Chemical Properties

• CAS DataBase Reference: ethyl [4-phenyl-5-pyridin-4-yl-3-thioxo-2,4-dihydro-3H-1,2,4-triazol-2-yl]carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [4-phenyl-5-pyridin-4-yl-3-thioxo-2,4-dihydro-3H-1,2,4-triazol-2-yl]carboxylate(1404079-95-3)
• EPA Substance Registry System: ethyl [4-phenyl-5-pyridin-4-yl-3-thioxo-2,4-dihydro-3H-1,2,4-triazol-2-yl]carboxylate(1404079-95-3)

Safety Data

• Hazardous Substances Data: 1404079-95-3(Hazardous Substances Data)

Upstream product

• 6954-50-3 1-isonicotinoyl-4-phenylthiosemicarbazide 
• 103-72-0 phenyl isothiocyanate 
• 54-85-3 isoniazid 
• 541-41-3 chloroformic acid ethyl ester 
• 16629-40-6 4-phenyl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

Synthesis and in-silico studies of some diaryltriazole derivatives as potential cyclooxygenase inhibitors

The synthesis of several 4-phenyl-5-pyridin-4-yl-2,3-dihydro-3H-1,2,4- triazole-3-thiones possessing N-2 Mannich bases or S-alkyl substituents, is reported. Several of them exhibited a low nanomolar COX enzyme inhibition activity. Most of the compounds sh

TRIAZOLE COMPOUNDS AS POTENTIAL ANTI-INFLAMMATORY AGENTS

The present invention relates to a compound of formula 1 or 2 wherein R1 represents straight-chain or branched C2-C8 alkyl, C2-C8 alkenyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6, alkyl amino group, or C2-C4 alkynyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6 alkyl amino group; and R2 represents hydroxyl, C1-C6 alkyl, C1-C6 alkylcarbonyl, di(C1-C6-alkyl)aminomethyl, C3-C6 heterocyclylmelhyl or arylaminomethyl, wherein the aryl group is optionally substituted by at least one substituent selected from the group consisting of halogens and C1-C6 alkoxy as well as associated pharmaceutical compositions and uses of the compound or composition in therapy, in particular for the treatment of a disorder or a disease susceptible to inhibition of COX-2.

Triazole compounds as anti-inflammatory agents

The present invention relates to a compound of formula 1. or 2 wherein R1 represents straight-chain or branched C2-C8 alkyl, C2-C8 alkenyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6 alkyl amino group, or C2-C4 alkynyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6 alkyl amino group; and R2 represents hydroxyl, C1-C6 alkyl, C1-C6 alkylcarbonyl, di(C1-C6-alkyl)aminomethyl, C3-C6 heterocyclylmethyl or arylaminomethyl, wherein the aryl group is optionally substituted by at least one substituent selected from the group consisting of halogens and C1-C6 alkoxy as well as associated pharmaceutical compositions and uses of the compound or composition in therapy, in particular for the treatment of a disorder or a disease susceptible to inhibition of COX-2.