1404115-87-2Relevant academic research and scientific papers
UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b] quinoline-2,4-diones in aqueous-glycerol medium
Nongthombam, Geetmani Singh,Kharmawlong, George Kupar,Kumar, John Elisa,Nongkhlaw, Rishanlang
, p. 9436 - 9442 (2018)
Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5-b]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperat
5-Arylpyrimido-[4,5-b]quinoline-diones as new and sustainable corrosion inhibitors for mild steel in 1 M HCl: A combined experimental and theoretical approach
Verma, Chandrabhan,Olasunkanmi,Obot,Ebenso, Eno E.,Quraishi
, p. 15639 - 15654 (2016/02/26)
The inhibition of mild steel corrosion in 1 M HCl by four 5-arylpyrimido-[4,5-b]quinoline-diones (APQDs), namely 5-(4-nitrophenyl)-5,10-dihydropyrimido [4,5-b]quinoline-2,4(1H,3H)-dione (APQD-1), 5-phenyl-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-di
Green synthesis of 5-aryl-(1H,3H,5H,10H)-pyrimido[4,5-b]quinoline-2,4- diones catalysed by 1,4-diazabicyclo[2.2.2]octane in water
Mosslemin, Mohammad Hossein,Hzarenezhad, Elham,Shams, Nasim,Rad, Mohammad Navid Soltani,Anaraki-Ardakani, Hossein,Fayazipoor, Rassol
, p. 169 - 171 (2014/04/17)
A green and efficient synthesis of 13 of the title compounds, three of which are novel, has been achieved via a one-pot, threecomponent reaction of anilines, aldehydes and barbituric acids, catalysed by 1,4-diaza-bicyclo[2.2.2] octane (DABCO) in water at reflux. Using microwave heating, reaction times were shortened from 12 h to under a minute and yields were generally higher.
L-Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: Regioselective synthesis of 5-arylpyrimido[4,5- b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water
Khalafi-Nezhad, Ali,Sarikhani, Samira,Shahidzadeh, Elham Shaikhi,Panahi, Farhad
, p. 2876 - 2884 (2012/11/13)
A green and efficient one-pot process to achieve 5-aryl-pyrimido[4,5-b] quinoline-dione derivatives, using a three-component reaction involving anilines, aldehydes and barbituric acids was developed. This protocol was accomplished efficiently using l-proline as catalyst in an aqueous medium to give the corresponding products in high yield. Also, 2-amino-4-arylquinoline-3- carbonitrile derivatives were obtained by replacing the barbituric acid with malononitrile in the designed protocol. The catalytic activity of l-proline in these reactions was tested over a set of aldehydes and amines, demonstrating that it is reactive towards a variety of functionalities. The multicomponent reactions showed good regioselectivity, and computational studies were used to investigate the selectivity.
