1404285-89-7Relevant academic research and scientific papers
Rhodium-Catalyzed Intramolecular Transannulation Reaction of Alkynyl Thiadiazole Enabled 5,n-Fused Thiophenes
Kim, Ji Eun,Lee, Jinsub,Yun, Hyunsik,Baek, Yonghyeon,Lee, Phil Ho
, p. 1437 - 1447 (2017)
A method for the synthesis of a wide range of fused thiophenes, including those fused with lactams, lactones, or cyclic ethers, was developed from a rhodium-catalyzed intramolecular transannulation reaction of alkynyl thiadiazoles. This transannulation reaction provides an efficient platform for the construction of a variety of 5,n-fused thiophenes from readily available starting materials together with the release of molecular nitrogen.
Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones
Meyer, Christina,Neue, Benedikt,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Würthwein, Ernst-Ulrich,Itami, Kenichiro,Wünsch, Bernhard
, p. 1844 - 1856 (2013/04/24)
The direct C-H-bond arylation of the complex spirocyclic lactones 13, 14, and 18 allows the introduction of diverse aryl moieties in the last step of the synthesis. A selective α-arylation of the thiophene moiety was performed with the catalytic system Pd
Late-stage C-H bond arylation of spirocyclic σ1 ligands for analysis of complementary σ1 receptor surface
Meyer, Christina,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Itami, Kenichiro,Wuensch, Bernhard
, p. 5972 - 5979 (2013/01/15)
Direct C-H bond arylation in the α- and β-positions of spirocyclic thiophenes containing various functional groups (amine, ether, acetal, lactone) was accomplished. Selective phenylation in the α-position of the thiophene ring was achieved by using the ca
