1404301-01-4Relevant articles and documents
Access to 2,3-disubstituted benzofurans through one-pot acid-catalyzed nucleophilic substitution/TBAF-mediated oxacycloisomerization
Raji Reddy, Chada,Krishna, Gaddam,Kavitha, Nerella,Latha, Bellamkonda,Shin, Dong-Soo
, p. 5381 - 5388 (2012/10/30)
An efficient synthetic strategy for the synthesis of diversely 2,3-disubstituted benzofurans is described. This method is based on the use of propargylic alcohols generated from TBS-protected ortho-hydroxy benzaldehydes as starting materials and allows a library of 2,3-disubstituted benzofurans to be built. The procedure consists of one-pot nucleophilic substitution, TBS-deprotection, and exo-dig cycloisomerization. Copyright