1404322-08-2

Upstream product

• 1606166-79-3 (R)-N-((S)-2-(2-fluorophenyl)pent-4-en-2-yl)-2-methylpropane-2-sulfinamide 
• 1346145-50-3 (R)-2-methylpropane-2-sulfinic acid [1-(2-fluorophenyl)-(E)-ethylidene]amide 
• 1404337-64-9 tert-butyl N-[(4S)-4-(5-amino-2-fluorophenyl)-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-2-yl]-N-[(tert-butoxy)-carbonyl]carbamate 
• 53234-55-2 5-cyano-pyridine-2-carboxylic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 1404337-23-0 C₃₇H₃₅F₂N₅O₆ 
• 1404337-20-7 C₃₀H₃₃F₂N₃O₅ 
• 1404337-16-1 C₃₂H₃₂F₅N₃O₆ 
• 1404337-13-8 (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-6-(hydroxymethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide 
• 1404337-02-5 (S)-(2-(bis(2,4-dimethoxybenzyl)amino)-4-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)-4-methyl-4H-1,3-oxazin-6-yl)methyl acetate 
• 1404336-99-7 C₃₅H₃₉F₄N₃O₈S 
• 1404336-97-5 C₃₄H₃₇F₄N₃O₈S 
• 1404336-94-2 C₁₆H₁₄F₄N₂O₄S 
• 1404336-92-0 C₁₅H₁₆F₄N₂O₄ 

Relevant academic research and scientific papers

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond to Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Accumulation of Aβ peptides is a hallmark of Alzheimer's disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key enzyme responsible for producing Aβ peptides, and thus agents that inhibit BACE1 should be bene

OXAZINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM

The present invention provides a compound of formula (I): wherein —X═ is —CR7═ or —N═,ring B is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle,R1 is substituted or unsubstituted alkyl or the l