1404440-02-3

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 23074-59-1 3-isobutoxycyclohex-2-en-1-one 
• 58775-64-7 3-[(methylthio)methyl]cyclohex-2-en-1-one 
• 58775-65-8 3-(iodomethyl)cyclohex-2-en-1-one 
• 305837-95-0 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 

Downstream Products

• 1204114-64-6 N-((3-hydroxycyclohex-1-en-1-yl)methyl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 
• 1354574-93-8 C₂₃H₂₅NO₄S 
• 1354574-78-9 9-benzoyl-7-tosyl-7-azaspiro[4.5]dec-9-en-1-one 
• 1404440-49-8 (Z)-4-(iodophenylmethylene)-2-tosyl-2-azaspiro[4.6]undec-7-ene 
• 1404440-34-1 N-((3-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)methyl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 
• 1404440-23-8 (Z)-4-(bromophenylmethylene)-2-tosyl-2-azaspiro[4.6]undec-7-ene 
• 1404440-15-8 (Z)-4-(chlorophenylmethylene)-2-tosyl-2-azaspiro[4.6]undec-7-ene 
• 1370511-68-4 (Z)-4-(bromo(phenyl)methylene)-2-tosyl-2-azaspiro[4.5]dec-6-ene 
• 1370511-60-6 (Z)-4-(chloro(phenyl)methylene)-2-tosyl-2-azaspiro[4.5]dec-6-ene 

Relevant academic research and scientific papers

Synthesis of 2-azaspiro[4.6]undec-7-enes from N -tosyl- N -(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols

The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.

Facile synthesis of azaspirocycles via iron trichloride-promoted cyclization/chlorination of cyclic 8-Aryl-5-aza-5-tosyl-2-en-7-yn-1-ols

A simple and efficient FeCl3-promoted cyclization/chlorination of cyclic tosylamine-tethered 8-aryl-2-en-7-yn-1-ols was observed. The reaction proceeded instantaneously at 23 °C in air to afford (Z)-4- (arylchloromethylene)-substituted azaspiro

Trifluoromethanesulfonic acid-catalyzed tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis reaction of arylpropagylsulfonamide- tethered 2,3-epoxycyclohexan-1-ols to spiropiperidines

A simple and efficient trifluoromethanesulfonic acid-catalyzed cycloisomerization of arylpropagylsulfonamide-tethered 2,3-epoxycyclohexan-1-ols is described. The cyclization proceeds via tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis to affo