1404440-46-5

Upstream product

• 1404440-60-3 5,5-dimethyl-3-(5-phenylpent-4-yn-1-yl)cyclohex-2-en-1-one 
• 4683-45-8 3-methoxy-5,5-dimethyl-cyclohex-2-enone 
• 1404440-62-5 4,4-dimethyl-6-(5-phenylpent-4-yn-1-yl)bicyclo[4.1.0]heptan-2-ol 
• 1404440-61-4 5,5-dimethyl-3-(5-phenylpent-4-yn-1-yl)cyclohex-2-en-1-ol 

Relevant academic research and scientific papers

Synthesis of 2-azaspiro[4.6]undec-7-enes from N -tosyl- N -(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols

The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.