1404459-18-2

Upstream product

• 1291069-95-8 (1S,3R,5S)-5-methyl-1-((2R,5R)-5-methyl-5-vinyltetrahydrofuran-2-yl)-2,8-dioxabicyclo[3.2.1]octane-3-carboxaldehyde 
• 1404458-60-1 (2S,5R,7S)-2-((E)-4-iodo-2-methylpenta-1,4-dien-1-yl)-7-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-1,6-dioxaspiro[4.5]decane 
• 180592-86-3 (2S,3S)-1-(4-methoxybenzyloxy)-2-methylhex-5-en-3-ol 
• 1404459-03-5 (2S,3S,Z)-10-tert-butyldimethylsilyloxy-1-(4-methoxybenzyloxy)-2-methyl-7-(trimethylsilylmethylene)decane-3-ol 
• 1404459-44-4 (8S,9S,Z)-8-hydroxy-10-(4-methoxybenzyloxy)-9-methyl-4-(trimethylsilylmethylene)decanal 
• 1404459-08-0 (2S,3S,10S,Z)-1-(4-methoxybenzyloxy)-2-methyl-7-(trimethylsilylmethylene)tridec-11-yne-3,10-diol 
• 1404459-46-6 (2S,3S,10S)-1-(4-methoxybenzyloxy)-2-methyl-7-methylenetridec-11-yne-3,10-diol 
• 1404459-11-5 (2S,5S,7S)-7-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-2-(prop-1-yn-1-yl)-1,6-dioxaspiro[4.5]decane 
• 1404459-52-4 (2S,5R,7S)-2-((E)-2-iodoprop-1-en-1-yl)-7-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-1,6-dioxaspiro[4.5]decane 

Relevant academic research and scientific papers

Synthesis of the C1-C26 hexacyclic subunit of pectenotoxin 2

Synthesis of the C1-C26 hexacyclic subunit of pectenotoxin-2 (PTX-2) is described that features a stereoselective annulation to generate the C-ring by triple asymmetric Nozaki-Hiyama-Kishi coupling followed by oxidative cyclization. Preparation of the C1-C14 AB spriroketal-containing subunit employs a recently developed metallacycle-mediated reductive cross-coupling between a TMS-alkyne and a terminal alkene.