1404530-70-6

Usage

Chemical structure

The compound contains a pyrazole ring, a pyridazine ring, a carboxylic acid group, a methoxybenzylamino group, and a methyl group attached to the pyrazole ring.

Potential pharmaceutical applications

The compound has potential applications in the field of medicinal chemistry due to its unique combination of structural elements.

Interaction with biological targets

The carboxylic acid group in the compound may allow it to interact with biological targets in the body, such as receptors or enzymes.

Solubility

The methoxybenzylamino group may contribute to the solubility of the compound, which is important for its pharmaceutical applications.

Binding to specific receptors or enzymes

The methoxybenzylamino group may also allow the compound to bind to specific receptors or enzymes, which could be useful in the development of targeted therapies.

Influence of the methyl group

The methyl group attached to the pyrazole ring may influence the biological activity of the compound, potentially affecting its efficacy or selectivity.

Promising candidate for research and development

The unique combination of structural elements in 1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carboxylic acid makes it a promising candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 1404530-67-1 1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1Hpyrazole-4-carboxylic acid ethyl ester 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 1404530-71-7 1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid 
• 1404530-76-2 Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate 
• 1404530-74-0 3-(1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazol-4-yl)-3-oxopropionic acid ethyl ester 

Relevant academic research and scientific papers

N -[6-(4-Butanoyl-5-methyl-1 H -pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1 H -indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization process leading to the identification of the preclinical candidate SAR216471. It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. SAR216471 displays potent in vivo antiplatelet and antithrombotic activities and has the potential to differentiate from other antiplatelet agents.

DERIVATIVES OF N-[(1H-PYRAZOL-1-YL)ARYL]-1H-INDOLE OR 1H-INDAZOLE-3-CARBOXAMIDE, PREPARATION THEREOF AND APPLICATIONS THEREOF IN THERAPEUTICS

The present invention relates to compounds corresponding to formula (I): in which: A represents a divalent aromatic radical; X represents a —CH— group or a nitrogen atom; R1 represents a (C1-C4)alkyl or a (C1-C4)alkoxy; R2 represents a group Alk; R3 represents a hydroxyl or a group —NR7R8; R4 represents a hydrogen atom, a halogen atom, a cyano, a phenyl, a group Alk, a group OAlk or a group —NR9R10; R5 represents a hydrogen atom, a halogen atom or a group Alk; R6 represents a hydrogen atom, a halogen atom, a cyano, a group —COOAlk or a —CONH2 group.

DERIVATIVES OF N- [(1H-PYRAZOL-1-YL) ARYL] - 1H - INDOLE OR 1H - INDAZOLE - 3 - CARBOXAMIDE, THEIR PREPARATION AND THEIR USE AS P2Y12 ANTAGONISTS

The present invention relates to compounds corresponding to formula (I) and their use as P2Y12 antagonists for the treatment of cardiovascular diseases.