1404532-70-2

Basic information

• Product Name: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester
• Synonyms: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester
• CAS NO: 1404532-70-2
• Molecular Weight: 537.413
• Mol File: 1404532-70-2.mol

Chemical Properties

• CAS DataBase Reference: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester(1404532-70-2)
• EPA Substance Registry System: {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester(1404532-70-2)

Safety Data

• Hazardous Substances Data: 1404532-70-2(Hazardous Substances Data)

Upstream product

• 1404530-84-2 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]butan-1-one 
• 1404530-82-0 ethyl 2-{[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]carbonyl}butanoate 
• 1404530-79-5 ethyl 3-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]-3-oxopropanoate 
• 350-46-9 4-Fluoronitrobenzene 
• 260973-82-8 5-methyl-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 1404530-78-4 1-[1-(4-aminophenyl)-5-methyl-1H-pyrazol-4-yl]butan-1-one 
• 1404532-12-2 5-bromo-1-(2-methoxy-2-oxoethyl)-1H-indole-3-carboxylic acid 
• 10406-06-1 5-bromo-1H-indole-3-carboxylic acid 
• 32387-18-1 1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone 
• 1404530-54-6 1-(5-methyl-1H-pyrazol-4-yl)butan-1-one 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 1404537-13-8 C₃₁H₃₃N₇O₃*ClH 
• 1404533-19-2 sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-cyano-indol-1-yl}acetate 
• 1404531-76-5 methyl (3-{[4-(4-butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-phenyl-1H-indol-1-yl)acetate 
• 1404531-81-2 {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-cyano-indol-1-yl}acetic acid methyl ester 

Relevant articles and documents

N -[6-(4-Butanoyl-5-methyl-1 H -pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1 H -indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization process leading to the identification of the preclinical candidate SAR216471. It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. SAR216471 displays potent in vivo antiplatelet and antithrombotic activities and has the potential to differentiate from other antiplatelet agents.

DERIVATIVES OF N-[(1H-PYRAZOL-1-YL)ARYL]-1H-INDOLE OR 1H-INDAZOLE-3-CARBOXAMIDE, PREPARATION THEREOF AND APPLICATIONS THEREOF IN THERAPEUTICS

The present invention relates to compounds corresponding to formula (I): in which: A represents a divalent aromatic radical; X represents a —CH— group or a nitrogen atom; R1 represents a (C1-C4)alkyl or a (C1-C4)alkoxy; R2 represents a group Alk; R3 represents a hydroxyl or a group —NR7R8; R4 represents a hydrogen atom, a halogen atom, a cyano, a phenyl, a group Alk, a group OAlk or a group —NR9R10; R5 represents a hydrogen atom, a halogen atom or a group Alk; R6 represents a hydrogen atom, a halogen atom, a cyano, a group —COOAlk or a —CONH2 group.

DERIVATIVES OF N- [(1H-PYRAZOL-1-YL) ARYL] - 1H - INDOLE OR 1H - INDAZOLE - 3 - CARBOXAMIDE, THEIR PREPARATION AND THEIR USE AS P2Y12 ANTAGONISTS

The present invention relates to compounds corresponding to formula (I) and their use as P2Y12 antagonists for the treatment of cardiovascular diseases.