1404575-82-1Relevant academic research and scientific papers
Metal-free direct: C -arylation of 1,3-dicarbonyl compounds and ethyl cyanoacetate: A platform to access diverse arrays of meta -functionalized phenols
Taneja, Neha,Peddinti, Rama Krishna
supporting information, p. 11423 - 11426 (2018/10/20)
A base mediated, highly convenient strategy for the direct C-arylation of 1,3-dicarbonyls and cyanoacetate with various phenol derivatives as aryl partners is presented. The present work excels in forming a C-C bond at the meta-position of the phenols, which is traditionally challenging to functionalize. This protocol further leads the way to have scalable, straightforward access to phenol assimilated heterocycles which have powerful applications both in synthetic chemistry and medicinal research.
Lewis Acid-Mediated Site-Selective Synthesis of Oxygenated Biaryls from Methoxyphenols and Electron-Rich Arenes
Sharma, Shivangi,Parumala, Santosh Kumar Reddy,Peddinti, Rama Krishna
, p. 9367 - 9383 (2017/09/22)
A rapid, efficient, and metal-free Lewis acid-mediated methodology has been developed for the site-selective synthesis of unsymmetrical oxygenated biaryls. This simple and efficient methodology furnished highly oxygenated and functionalized unsymmetrical biaryls in good to excellent yields by the direct oxidative coupling of electron-rich arenes to the α-position of carbonyl functionality of in situ generated masked benzoquinones.
[3+2] Cycloaddition of masked o-benzoquinones with azomethine ylides
Chittimalla, Santhosh Kumar,Kuppusamy, Rajesh,Chakrabarti, Anjan
experimental part, p. 1901 - 1906 (2012/09/22)
A simple and efficient access to highly functionalized isoindolone derivatives via a [3+2] cycloaddition process between in situ generated azomethine ylides with various stable (isolable) masked o-benzoquinones is described. This approach allows a rapid and general synthesis of isoindolones with substituents to further manipulate and elaborate the structural complexity. Georg Thieme Verlag Stuttgart · New York.
