14048-15-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-2,4-dimethoxypyrimidine is used as a key intermediate in the synthesis of potent cytotoxic and antimitotic agents. Its unique chemical structure allows for the development of compounds that can effectively target and inhibit the growth of cancer cells, making it a valuable component in the creation of new anticancer drugs.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, 5-Amino-2,4-dimethoxypyrimidine can also be utilized in the synthesis of various other chemical compounds. Its versatile structure enables it to be a building block for a wide range of molecules with potential applications in different industries, such as agrochemicals, dyes, and materials science.

Upstream product

• 30561-07-0 5-nitro-2,4-dimethoxypyrimidine 
• 5177-27-5 5-amino-2,4-dichloropyrimidine 
• 124-41-4 sodium methylate 

Downstream Products

• 7749-25-9 sulfanilic acid-(2,4-dimethoxy-pyrimidin-5-ylamide) 
• 107682-86-0 N-acetyl-sulfanilic acid-(2,4-dimethoxy-pyrimidin-5-ylamide) 
• 100376-12-3 4-chloro-2-(2,4-dimethoxy-pyrimidin-5-ylamino)-benzoic acid 
• 1608498-12-9 C₂₀H₂₇N₃O₃ 

Relevant academic research and scientific papers

1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53

The invention relates to 1,2,3',5'-tetrahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.

N-SUBSTITUTED 4-AMINOPHENOLS AND CORRESPONDING QUINONE IMINES

Compounds of formula I or formula II, wherein Q1Q3 and R1-R5 are as defined in the claims, exhibit CytC derived peroxidase inhibiting activity and are thus useful as CytC derived peroxidase inhibiting agents.

Oxidative amination of cuprated pyrimidine and purine derivatives

Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.

1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R 1, R 3, R 4, R 5, Z, Y, V, X, X', J, K, L, and M are as defined herein.